Differential impact of mammalian target of rapamycin inhibition on CD4(+)CD25(+)Foxp3(+) regulatory T cells compared with conventional CD4(+) T cells

Based on their ability to control T-cell homeostasis, Foxp3(+)CD4(+)CD25(+) regulatory T cells (Tregs) are being considered for treatment of autoimmune disorders and acute graft-versus-host disease (aGVHD). When combining Tregs with the immunosuppressant rapamycin (RAPA), we observed reduced allorea...

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Detalhes bibliográficos
Main Authors: Zeiser, Robert, Leveson-Gower, Dennis B., Zambricki, Elizabeth A., Kambham, Neeraja, Beilhack, Andreas, Loh, John, Hou, Jing-Zhou, Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200823/
https://ncbi.nlm.nih.gov/pubmed/17967941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094482
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