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Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4(+)CD25(+)Foxp3(+) regulatory T cells
Previous work has demonstrated that both rapamycin (RAPA) and IL-2 enhance CD4(+)CD25(+)Foxp3(+) regulatory T-cell (Treg) proliferation and function in vitro. We investigated whether the combination of RAPA plus IL-2 could impact acute GVHD induction after bone marrow transplantation (BMT). RAPA plu...
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| Publié dans: | Blood |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4467868/ https://ncbi.nlm.nih.gov/pubmed/21734238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-313684 |
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