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Host derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease

Interleukin (IL)-18 stimulates T helper 1 (Th1) and Th2-mediated immune responses and has been shown to modulate acute graft-versus-host disease (aGvHD). It is still unknown whether increased IL-18 levels during aGvHD are of host or donor origin and how the absence of IL-18 impacts migration and exp...

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Main Authors: Zeiser, Robert, Zambricki, Elizabeth A., Leveson-Gower, Dennis, Kambham, Neeraja, Beilhack, Andreas, Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699940/
https://ncbi.nlm.nih.gov/pubmed/18022572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2007.08.041
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