Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4–dependent mechanism

CD4(+) natural killer T (NKT) cells, along with CD4(+)CD25(+) regulatory T cells (Tregs), are capable of controlling aberrant immune reactions. We explored the adoptive transfer of highly purified (> 95%) CD4(+)NKT cells in a murine model of allogeneic hematopoietic cell transplantation (HCT). NK...

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Detalhes bibliográficos
Main Authors: Leveson-Gower, Dennis B., Olson, Janelle A., Sega, Emanuela I., Luong, Richard H., Baker, Jeanette, Zeiser, Robert, Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317770/
https://ncbi.nlm.nih.gov/pubmed/21258007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-303008
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