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Early CD30 signaling is critical for adoptively transferred CD4(+)CD25(+) regulatory T cells in prevention of acute graft-versus-host disease
Murine CD4(+)CD25(+) regulatory T cells (Treg cells) reduce acute graft-versus-host disease (aGvHD). However, surface molecules critical for suppression are unclear. Deficiency of CD30 (CD30(−/−)) leads to impaired thymic negative selection and augmented T-cell autoreactivity. Therefore, we investig...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1801065/ https://ncbi.nlm.nih.gov/pubmed/17068147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-07-038455 |
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