Early CD30 signaling is critical for adoptively transferred CD4(+)CD25(+) regulatory T cells in prevention of acute graft-versus-host disease

Murine CD4(+)CD25(+) regulatory T cells (Treg cells) reduce acute graft-versus-host disease (aGvHD). However, surface molecules critical for suppression are unclear. Deficiency of CD30 (CD30(−/−)) leads to impaired thymic negative selection and augmented T-cell autoreactivity. Therefore, we investig...

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Main Authors: Zeiser, Robert, Nguyen, Vu H., Hou, Jing-Zhou, Beilhack, Andreas, Zambricki, Elizabeth, Buess, Martin, Contag, Christopher H., Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2007
Assuntos:
Transplantation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801065/
https://ncbi.nlm.nih.gov/pubmed/17068147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-07-038455
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