The factor VIII C1 domain contributes to platelet binding

Activated factor VIII (FVIIIa) forms a procoagulant complex with factor IXa on negatively charged membranes, including activated platelet surfaces. Membrane attachment involves the FVIII C2 domain; involvement of the adjacent C1 domain has not been established. Binding of recombinant FVIII C1C2 and...

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Bibliographic Details
Main Authors: Hsu, Ting-Chang, Pratt, Kathleen P., Thompson, Arthur R.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200805/
https://ncbi.nlm.nih.gov/pubmed/17916745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-068957
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