Factor I is required for the development of membranoproliferative glomerulonephritis in factor H–deficient mice

The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) is associated with dysregulation of the alternative pathway of complement activation. MPGN2 is characterized by the presence of complement C3 along the glomerular basement membrane (GBM). Spontaneous activation...

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Autori principali: Rose, Kirsten L., Paixao-Cavalcante, Danielle, Fish, Jennifer, Manderson, Anthony P., Malik, Talat H., Bygrave, Anne E., Lin, Tao, Sacks, Steven H., Walport, Mark J., Cook, H. Terence, Botto, Marina, Pickering, Matthew C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200299/
https://ncbi.nlm.nih.gov/pubmed/18202746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32525
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