Factor I is required for the development of membranoproliferative glomerulonephritis in factor H–deficient mice

The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) is associated with dysregulation of the alternative pathway of complement activation. MPGN2 is characterized by the presence of complement C3 along the glomerular basement membrane (GBM). Spontaneous activation...

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Detalhes bibliográficos
Main Authors: Rose, Kirsten L., Paixao-Cavalcante, Danielle, Fish, Jennifer, Manderson, Anthony P., Malik, Talat H., Bygrave, Anne E., Lin, Tao, Sacks, Steven H., Walport, Mark J., Cook, H. Terence, Botto, Marina, Pickering, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200299/
https://ncbi.nlm.nih.gov/pubmed/18202746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32525
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