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The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
We investigated the relationship between PS1 and γ-secretase processing of amyloid precursor protein (APP) in primary cultures of neurons. Increasing the amount of APP at the cell surface or towards endosomes did not significantly affect PS1-dependent γ-secretase cleavage, although little PS1 is pre...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
The Rockefeller University Press
2001
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2196466/ https://ncbi.nlm.nih.gov/pubmed/11502763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200104045 |
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