The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein

We investigated the relationship between PS1 and γ-secretase processing of amyloid precursor protein (APP) in primary cultures of neurons. Increasing the amount of APP at the cell surface or towards endosomes did not significantly affect PS1-dependent γ-secretase cleavage, although little PS1 is pre...

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Bibliographische Detailangaben
Hauptverfasser: Cupers, Philippe, Bentahir, Mustapha, Craessaerts, Katleen, Orlans, Isabelle, Vanderstichele, Hugo, Saftig, Paul, De Strooper, Bart, Annaert, Wim
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2001
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196466/
https://ncbi.nlm.nih.gov/pubmed/11502763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200104045
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