Lineage Commitment in the Thymus: Only the Most Differentiated (TCR(hi)bcl-2(hi)) Subset of CD4(+)CD8(+)Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis

Eitemau Tebyg

• Commitment of Immature CD4(+)8(+) Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains
  gan: Suzuki, Harumi, et al.
  Cyhoeddwyd: (1997)
• T Cell Receptor (TCR)-induced Death of Immature CD4(+)CD8(+) Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus
  gan: Punt, Jennifer A., et al.
  Cyhoeddwyd: (1997)
• The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus
  Cyhoeddwyd: (1994)
• The organotin-induced thymus atrophy, characterized by depletion of CD4+ CD8+ thymocytes, is preceded by a reduction of the immature CD4- CD8+ TcR alpha beta-/low CD2high thymoblast subset.
  gan: Pieters, R H, et al.
  Cyhoeddwyd: (1992)
• CD8 Coreceptor Extinction in Signaled CD4(+)CD8(+) Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes
  gan: Cibotti, Ricardo, et al.
  Cyhoeddwyd: (2000)