Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct

The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2′-deoxy-β-d-erythro-pentofuranosyl)-pyrimido[1,2-a]purin-10(3H)-one (M(1)G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG)⋅d(CGGACACC) or d(AT...

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Main Authors: Mao, Hui, Schnetz-Boutaud, Nathalie C., Weisenseel, Jason P., Marnett, Lawrence J., Stone, Michael P.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Physical Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC21963/
https://ncbi.nlm.nih.gov/pubmed/10359760
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