Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct

The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2′-deoxy-β-d-erythro-pentofuranosyl)-pyrimido[1,2-a]purin-10(3H)-one (M(1)G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG)⋅d(CGGACACC) or d(AT...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Mao, Hui, Schnetz-Boutaud, Nathalie C., Weisenseel, Jason P., Marnett, Lawrence J., Stone, Michael P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Physical Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21963/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359760/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6615
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