A 32P-postlabeling method for detecting unstable N-7-substituted deoxyguanosine adducts in DNA.

Many antitumor agents, including the mustards, form N-7 deoxyguanosine adducts in DNA that are difficult to quantitate by the 32P-postlabeling procedure because of their instability. We have developed a method that is successful for the analysis of such adducts using, as a prototype mustard, 14C-lab...

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Detaylı Bibliyografya
Asıl Yazarlar: Yu, D, Niu, T Q, Austin-Ritchie, P, Ludlum, D B
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1994
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC44373/
https://ncbi.nlm.nih.gov/pubmed/8041772
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