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Bulge Migration of the Malondialdehdye OPdG DNA Adduct When Placed Opposite a Two-Base Deletion in the (CpG)(3) Frameshift Hotspot of the Salmonella typhimurium hisD3052 Gene
The OPdG adduct N(2)-(3-oxo-1-propenyl)dG, formed in DNA exposed to malondialdehyde, was introduced into 5′-d(ATCGCXCGGCATG)-3′•5′-d(CATGCCGCGAT)-3′ at pH 7 (X = OPdG). The OPdG adduct is the base-catalyzed rearrangement product of the M(1)dG adduct, 3-(β-d-ribofuranosyl)pyrimido[1,2-a]purin-10(3H)-...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2728581/ https://ncbi.nlm.nih.gov/pubmed/17645303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700121j |
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