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Bulge Migration of the Malondialdehdye OPdG DNA Adduct When Placed Opposite a Two-Base Deletion in the (CpG)(3) Frameshift Hotspot of the Salmonella typhimurium hisD3052 Gene
The OPdG adduct N(2)-(3-oxo-1-propenyl)dG, formed in DNA exposed to malondialdehyde, was introduced into 5′-d(ATCGCXCGGCATG)-3′•5′-d(CATGCCGCGAT)-3′ at pH 7 (X = OPdG). The OPdG adduct is the base-catalyzed rearrangement product of the M(1)dG adduct, 3-(β-d-ribofuranosyl)pyrimido[1,2-a]purin-10(3H)-...
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| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2007
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2728581/ https://ncbi.nlm.nih.gov/pubmed/17645303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700121j |
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