Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25(+) Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

Therapeutic efficacy of a tumor cell–based vaccine against experimental B16 melanoma requires the disruption of either of two immunoregulatory mechanisms that control autoreactive T cell responses: the cytotoxic T lymphocyte–associated antigen (CTLA)-4 pathway or the CD25(+) regulatory T (Treg) cell...

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Detalhes bibliográficos
Main Authors: Sutmuller, Roger P.M., van Duivenvoorde, Leonie M., van Elsas, Andrea, Schumacher, Ton N.M., Wildenberg, Manon E., Allison, James P., Toes, Rene E.M., Offringa, Rienk, Melief, Cornelis J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195955/
https://ncbi.nlm.nih.gov/pubmed/11560997
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