Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion

Vaccines harboring genes that encode functional oncoproteins are intrinsically hazardous, as their application may lead to introduction of these genes into normal cells and thereby to tumorigenesis. On the other hand, oncoproteins are especially attractive targets for immunotherapy of cancer, as the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Toes, René E. M., Hoeben, Rob C., van der Voort, Ellen I. H., Ressing, Maaike E., van der Eb, Alex J., Melief, Cornelis J. M., Offringa, Rienk
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25085/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14660
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