Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion

Vaccines harboring genes that encode functional oncoproteins are intrinsically hazardous, as their application may lead to introduction of these genes into normal cells and thereby to tumorigenesis. On the other hand, oncoproteins are especially attractive targets for immunotherapy of cancer, as the...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Toes, René E. M., Hoeben, Rob C., van der Voort, Ellen I. H., Ressing, Maaike E., van der Eb, Alex J., Melief, Cornelis J. M., Offringa, Rienk
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25085/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14660
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