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Genetic heterogeneity in response to adenovirus gene therapy

BACKGROUND: After intravenous delivery of the adenoviral vector into rats or mice, 95–99% of the encoded protein is produced in the hepatocytes. We observed, as have others, that the early expression levels of the vector encoded protein vary, greatly, within a species, from one animal strain to anot...

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Autors principals: Lefesvre, Pierre, Attema, Joline, Lemckert, Angelique, Havenga, Menzo, Bekkum, Dirk van
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC155537/
https://ncbi.nlm.nih.gov/pubmed/12697054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-4-4
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