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A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene
The c-kit gene encodes a receptor tyrosine kinase, whose engagement by its ligand triggers signals leading to cell proliferation. c-kit activity is elevated in gastrointestinal stromal tumors (GISTs), and its therapeutic inhibition by small molecules such as imatinib is clinically validated. We iden...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2195898/ https://ncbi.nlm.nih.gov/pubmed/16784237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0601510 |
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