A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene

The c-kit gene encodes a receptor tyrosine kinase, whose engagement by its ligand triggers signals leading to cell proliferation. c-kit activity is elevated in gastrointestinal stromal tumors (GISTs), and its therapeutic inhibition by small molecules such as imatinib is clinically validated. We iden...

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Bibliografiske detaljer
Main Authors: Fernando, Himesh, Reszka, Anthony P., Huppert, Julian, Ladame, Sylvain, Rankin, Sarah, Venkitaraman, Ashok R., Neidle, Stephen, Balasubramanian, Shankar
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195898/
https://ncbi.nlm.nih.gov/pubmed/16784237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0601510
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