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Deficiency of the Stress Kinase P38α Results in Embryonic Lethality: Characterization of the Kinase Dependence of Stress Responses of Enzyme-Deficient Embryonic Stem Cells
The mitogen-activated protein (MAP) kinase p38 is a key component of stress response pathways and the target of cytokine-suppressing antiinflammatory drugs (CSAIDs). A genetic approach was employed to inactivate the gene encoding one p38 isoform, p38α. Mice null for the p38α allele die during embryo...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2000
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2195860/ https://ncbi.nlm.nih.gov/pubmed/10704466 |
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