Complete antithrombin deficiency in mice results in embryonic lethality

Antithrombin is a plasma protease inhibitor that inhibits thrombin and contributes to the maintenance of blood fluidity. Using targeted gene disruption, we investigated the role of antithrombin in embryogenesis. Mating mice heterozygous for antithrombin gene (ATIII) disruption, ATIII(+/–), yielded t...

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Main Authors: Ishiguro, Kazuhiro, Kojima, Tetsuhito, Kadomatsu, Kenji, Nakayama, Yukiko, Takagi, Akira, Suzuki, Misao, Takeda, Naoki, Ito, Masafumi, Yamamoto, Koji, Matsushita, Tadashi, Kusugami, Kazuo, Muramatsu, Takashi, Saito, Hidehiko
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2000
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC517819/
https://ncbi.nlm.nih.gov/pubmed/11018075
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