Complete antithrombin deficiency in mice results in embryonic lethality

Antithrombin is a plasma protease inhibitor that inhibits thrombin and contributes to the maintenance of blood fluidity. Using targeted gene disruption, we investigated the role of antithrombin in embryogenesis. Mating mice heterozygous for antithrombin gene (ATIII) disruption, ATIII(+/–), yielded t...

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Autori principali: Ishiguro, Kazuhiro, Kojima, Tetsuhito, Kadomatsu, Kenji, Nakayama, Yukiko, Takagi, Akira, Suzuki, Misao, Takeda, Naoki, Ito, Masafumi, Yamamoto, Koji, Matsushita, Tadashi, Kusugami, Kazuo, Muramatsu, Takashi, Saito, Hidehiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC517819/
https://ncbi.nlm.nih.gov/pubmed/11018075
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