Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis

von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also exogenous modulators that induce VWF-platelet aggregation. Sulfatides, 3-sulfated galactosyl ceramide...

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Bibliographic Details
Main Authors: Nakayama, Takayuki, Matsushita, Tadashi, Yamamoto, Koji, Mutsuga, Noriko, Kojima, Tetsuhito, Katsumi, Akira, Nakao, Norihiko, Sadler, J. Evan, Naoe, Tomoki, Saito, Hidehiko
Format: Artigo
Language:Inglês
Published: Springer Japan 2008
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668596/
https://ncbi.nlm.nih.gov/pubmed/18369690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12185-008-0065-8
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