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Early Embryonic Lethality Caused by Disruption of the Gene for Choline Kinase α, the First Enzyme in Phosphatidylcholine Biosynthesis
Choline kinase α (CK-α) is one of two mammalian enzymes that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the major membrane phospholipid, phosphatidylcholine. We created mice lacking CK-α with an embryonic stem cell line containing an insertional mutation in the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3033886/ https://ncbi.nlm.nih.gov/pubmed/18029352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708766200 |
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