High-throughput Screening in Embryonic Stem Cell-derived Neurons Identifies Potentiators of α-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type Glutamate Receptors

Stem cell biology offers advantages to investigators seeking to identify new therapeutic molecules. Specifically, stem cells are genetically stable, scalable for molecular screening, and function in cellular assays for drug efficacy and safety. A key hurdle for drug discoverers of central nervous sy...

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Detalhes bibliográficos
Main Authors: McNeish, John, Roach, Marsha, Hambor, John, Mather, Robert J., Weibley, Laura, Lazzaro, John, Gazard, Justin, Schwarz, Jacob, Volkmann, Robert, Machacek, David, Stice, Steve, Zawadzke, Laura, O'Donnell, Christopher, Hurst, Raymond
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878023/
https://ncbi.nlm.nih.gov/pubmed/20212047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.098814
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