Targeted Deletion of a Distant Transcriptional Enhancer of the Receptor Activator of Nuclear Factor-κB Ligand Gene Reduces Bone Remodeling and Increases Bone Mass

Receptor activator of nuclear factor-κB ligand (RANKL) is essential for osteoclast differentiation, and hormones and cytokines that stimulate bone resorption increase RANKL expression in stromal/osteoblastic cells. We have previously shown that PTH and 1,25-dihydroxyvitamin D(3) control murine RANKL...

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Detalhes bibliográficos
Main Authors: Galli, Carlo, Zella, Lee A., Fretz, Jackie A., Fu, Qiang, Pike, J. Wesley, Weinstein, Robert S., Manolagas, Stavros C., O’Brien, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194617/
https://ncbi.nlm.nih.gov/pubmed/17932217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-0734
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