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Impaired V(D)J Recombination and Lymphocyte Development in Core RAG1-expressing Mice

RAG1 and RAG2 are the lymphocyte-specific components of the V(D)J recombinase. In vitro analyses of RAG function have relied on soluble, highly truncated “core” RAG proteins. To identify potential functions for noncore regions and assess functionality of core RAG1 in vivo, we generated core RAG1 kno...

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書誌詳細
主要な著者: Dudley, Darryll D., Sekiguchi, JoAnn, Zhu, Chengming, Sadofsky, Moshe J., Whitlow, Scott, DeVido, Jeffrey, Monroe, Robert J., Bassing, Craig H., Alt, Frederick W.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194253/
https://ncbi.nlm.nih.gov/pubmed/14581608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030627
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