Impaired V(D)J Recombination and Lymphocyte Development in Core RAG1-expressing Mice

RAG1 and RAG2 are the lymphocyte-specific components of the V(D)J recombinase. In vitro analyses of RAG function have relied on soluble, highly truncated “core” RAG proteins. To identify potential functions for noncore regions and assess functionality of core RAG1 in vivo, we generated core RAG1 kno...

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Auteurs principaux: Dudley, Darryll D., Sekiguchi, JoAnn, Zhu, Chengming, Sadofsky, Moshe J., Whitlow, Scott, DeVido, Jeffrey, Monroe, Robert J., Bassing, Craig H., Alt, Frederick W.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2003
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194253/
https://ncbi.nlm.nih.gov/pubmed/14581608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030627
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