The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcɛRI-mediated Mast Cell Activation

The linker for activation of T cells (LAT) is an adaptor protein critical for FcɛRI-mediated mast cell activation. LAT is a substrate of the tyrosine kinases activated after TCR and FcɛRI engagement. After phosphorylation of the cytosolic domain of LAT, multiple signaling molecules such as phospholi...

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Hlavní autoři: Saitoh, Shin-ichiroh, Odom, Sandra, Gomez, Gregorio, Sommers, Connie L., Young, Howard A., Rivera, Juan, Samelson, Lawrence E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2003
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194190/
https://ncbi.nlm.nih.gov/pubmed/12953098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030574
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