Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

Interleukin (IL) 23 is a heterodimeric cytokine composed of a p19 subunit and the p40 subunit of IL-12. IL-23 affects memory T cell and inflammatory macrophage function through engagement of a novel receptor (IL-23R) on these cells. Recent analysis of the contribution of IL-12 and IL-23 to central n...

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Hlavní autoři: Murphy, Craig A., Langrish, Claire L., Chen, Yi, Blumenschein, Wendy, McClanahan, Terrill, Kastelein, Robert A., Sedgwick, Jonathon D., Cua, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2003
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194162/
https://ncbi.nlm.nih.gov/pubmed/14662908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030896
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