Proteolytic Processing of Stat6 Signaling in Mast Cells as a Negative Regulatory Mechanism

Accumulating evidence has shown the importance of Stat6-mediated signaling in allergic diseases. In this study, we show a novel regulatory mechanism of Stat6-mediated signaling in mast cells. When Stat6 is activated by interleukin (IL)-4 and translocated to the nucleus, Stat6 is cleaved by a nucleus...

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Detalhes bibliográficos
Main Authors: Suzuki, Kotaro, Nakajima, Hiroshi, Kagami, Shin-ichiro, Suto, Akira, Ikeda, Kei, Hirose, Koichi, Hiwasa, Takaki, Takeda, Kiyoshi, Saito, Yasushi, Akira, Shizuo, Iwamoto, Itsuo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194019/
https://ncbi.nlm.nih.gov/pubmed/12093868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011682
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