Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3

Stat3 signaling is essential for the induction of RORγt and subsequent Th17 cell differentiation. However, the downstream targets of Stat3 for RORγt expression remain largely unknown. We show here that a novel isoform of Sox5, named Sox5t, is induced in Th17 cells in a Stat3-dependent manner. In viv...

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Detalhes bibliográficos
Main Authors: Tanaka, Shigeru, Suto, Akira, Iwamoto, Taro, Kashiwakuma, Daisuke, Kagami, Shin-ichiro, Suzuki, Kotaro, Takatori, Hiroaki, Tamachi, Tomohiro, Hirose, Koichi, Onodera, Atsushi, Suzuki, Junpei, Ohara, Osamu, Yamashita, Masakatsu, Nakayama, Toshinori, Nakajima, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144730/
https://ncbi.nlm.nih.gov/pubmed/25073789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130791
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