Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3

Stat3 signaling is essential for the induction of RORγt and subsequent Th17 cell differentiation. However, the downstream targets of Stat3 for RORγt expression remain largely unknown. We show here that a novel isoform of Sox5, named Sox5t, is induced in Th17 cells in a Stat3-dependent manner. In viv...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Tanaka, Shigeru, Suto, Akira, Iwamoto, Taro, Kashiwakuma, Daisuke, Kagami, Shin-ichiro, Suzuki, Kotaro, Takatori, Hiroaki, Tamachi, Tomohiro, Hirose, Koichi, Onodera, Atsushi, Suzuki, Junpei, Ohara, Osamu, Yamashita, Masakatsu, Nakayama, Toshinori, Nakajima, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2014
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144730/
https://ncbi.nlm.nih.gov/pubmed/25073789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130791
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares