Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8(+) T Cells

Transgenic (TG) mice expressing a high copy number of interleukin (IL)-7 cDNA under the control of the major histocomaptability complex (MHC) class II promoter display a 10–20-fold increase in total T cell numbers. Here, we show that the increase in T cell numbers in IL-7 TG mice is most apparent at...

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Autores principales: Kieper, William C., Tan, Joyce T., Bondi-Boyd, Brea, Gapin, Laurent, Sprent, Jonathan, Ceredig, Rhodri, Surh, Charles D.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193553/
https://ncbi.nlm.nih.gov/pubmed/12070281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020067
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