Converting IL-15 to a superagonist by binding to soluble IL-15Rα

IL-15 is normally presented in vivo as a cell-associated cytokine bound to IL-15Rα. We show here that the biological activity of soluble IL-15 is much improved after interaction with recombinant soluble IL-15Rα; after injection, soluble IL-15/IL-15Rα complexes rapidly induce strong and selective exp...

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Bibliografiske detaljer
Main Authors: Rubinstein, Mark P., Kovar, Marek, Purton, Jared F., Cho, Jae-Ho, Boyman, Onur, Surh, Charles D., Sprent, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482584/
https://ncbi.nlm.nih.gov/pubmed/16757567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600240103
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