IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25

IL-2 is crucial to T cell homeostasis, especially of CD4(+) T regulatory cells and memory CD8(+) cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown...

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Bibliografische gegevens
Hoofdauteurs: Létourneau, Sven, van Leeuwen, Ester M. M., Krieg, Carsten, Martin, Chris, Pantaleo, Giuseppe, Sprent, Jonathan, Surh, Charles D., Boyman, Onur
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2010
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836659/
https://ncbi.nlm.nih.gov/pubmed/20133862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909384107
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