Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line: A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling

Somatic cell mutagenesis is a powerful tool for characterizing receptor systems. We reported previously two complementation groups of mutant cell lines derived from CD14-transfected Chinese hamster ovary–K1 fibroblasts defective in responses to bacterial endotoxin. Both classes of mutants expressed...

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Autori principali: Schromm, Andra B., Lien, Egil, Henneke, Philipp, Chow, Jesse C., Yoshimura, Atsutoshi, Heine, Holger, Latz, Eicke, Monks, Brian G., Schwartz, David A., Miyake, Kensuke, Golenbock, Douglas T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2001
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193443/
https://ncbi.nlm.nih.gov/pubmed/11435474
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