Short Telomeres Result in Organismal Hypersensitivity to Ionizing Radiation in Mammals

Here we show a correlation between telomere length and organismal sensitivity to ionizing radiation (IR) in mammals. In particular, fifth generation (G5) mouse telomerase RNA (mTR)(−/)− mice, with telomeres 40% shorter than in wild-type mice, are hypersensitive to cumulative doses of gamma rays. 60%...

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Hlavní autoři: Goytisolo, Fermín A., Samper, Enrique, Martín-Caballero, Juan, Finnon, Paul, Herrera, Eloísa, Flores, Juana M., Bouffler, Simon D., Blasco, María A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2000
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193093/
https://ncbi.nlm.nih.gov/pubmed/11104804
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