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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres.
Mice deficient for the mouse telomerase RNA (mTR-/-) and lacking telomerase activity can only be bred for approximately six generations due to decreased male and female fertility and to an increased embryonic lethality associated with a neural tube closure defect. Although late generation mTR-/- mic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171377/ https://ncbi.nlm.nih.gov/pubmed/10357808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.11.2950 |
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