Disease states associated with telomerase deficiency appear earlier in mice with short telomeres.

Mice deficient for the mouse telomerase RNA (mTR-/-) and lacking telomerase activity can only be bred for approximately six generations due to decreased male and female fertility and to an increased embryonic lethality associated with a neural tube closure defect. Although late generation mTR-/- mic...

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Библиографические подробности
Главные авторы: Herrera, E, Samper, E, Martín-Caballero, J, Flores, J M, Lee, H W, Blasco, M A
Формат: Artigo
Язык:Inglês
Опубликовано: 1999
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171377/
https://ncbi.nlm.nih.gov/pubmed/10357808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.11.2950
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