Retinoic Acid and Arsenic Synergize to Eradicate Leukemic Cells in a Mouse Model of Acute Promyelocytic Leukemia

In acute promyelocytic leukemia (APL) patients, retinoic acid (RA) triggers differentiation while arsenic trioxide (arsenic) induces both a partial differentiation and apoptosis. Although their mechanisms of action are believed to be distinct, these two drugs both induce the catabolism of the oncoge...

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Autores principales: Lallemand-Breitenbach, Valérie, Guillemin, Marie-Claude, Janin, Anne, Daniel, Marie-Thérèse, Degos, Laurent, Kogan, Scott C., Michael Bishop, J., de Thé, Hugues
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 1999
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193002/
https://ncbi.nlm.nih.gov/pubmed/10190895
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