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Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

Little is known about the events triggering lymphocyte invasion of the pancreatic islets in prelude to autoimmune diabetes. For example, where islet-reactive T cells first encounter antigen has not been identified. We addressed this issue using BDC2.5 T cell receptor transgenic mice, which express a...

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Detalhes bibliográficos
Main Authors: Höglund, Petter, Mintern, Justine, Waltzinger, Caroline, Heath, William, Benoist, Christophe, Mathis, Diane
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192987/
https://ncbi.nlm.nih.gov/pubmed/9892615
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