Selective, covalent modification of β-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors

Microtubules are linear polymers of α- and β-tubulin heterodimers and are the major constituents of mitotic spindles, which are essential for the separation of chromosomes during mitosis. Here we describe a synthetic compound, 2-fluoro-1-methoxy-4-pentafluorophenylsulfonamidobenzene (T138067), which...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Shan, Bei, Medina, Julio C., Santha, Edit, Frankmoelle, Walter P., Chou, Ting-C., Learned, Robert M., Narbut, Mathew R., Stott, Dean, Wu, Pengguang, Jaen, Juan C., Rosen, Terry, Timmermans, Pieter B. M. W. M., Beckmann, Holger
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21921/
https://ncbi.nlm.nih.gov/pubmed/10318945
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker