Selective, covalent modification of β-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors

Microtubules are linear polymers of α- and β-tubulin heterodimers and are the major constituents of mitotic spindles, which are essential for the separation of chromosomes during mitosis. Here we describe a synthetic compound, 2-fluoro-1-methoxy-4-pentafluorophenylsulfonamidobenzene (T138067), which...

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Detalhes bibliográficos
Main Authors: Shan, Bei, Medina, Julio C., Santha, Edit, Frankmoelle, Walter P., Chou, Ting-C., Learned, Robert M., Narbut, Mathew R., Stott, Dean, Wu, Pengguang, Jaen, Juan C., Rosen, Terry, Timmermans, Pieter B. M. W. M., Beckmann, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21921/
https://ncbi.nlm.nih.gov/pubmed/10318945
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