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Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements
Symmetries in the p53 response-element (p53RE) encode binding modes for p53 tetramer to recognize DNA. We investigated the molecular mechanisms and biological implications of the possible binding modes. The probabilities evaluated with molecular dynamics simulations and DNA sequence analyses were fo...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2190717/ https://ncbi.nlm.nih.gov/pubmed/17986463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm890 |
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