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Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice

The lack of a specific biomarker makes preclinical diagnosis of Alzheimer's disease (AD) impossible, and it precludes assessment of therapies aimed at preventing or reversing the course of the disease. The development of a tool that enables direct, quantitative detection of the amyloid-β deposi...

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Главные авторы: Bacskai, Brian J., Hickey, Gregory A., Skoch, Jesse, Kajdasz, Stephen T., Wang, Yanming, Huang, Guo-feng, Mathis, Chester A., Klunk, William E., Hyman, Bradley T.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2003
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC218780/
https://ncbi.nlm.nih.gov/pubmed/14517353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2034101100
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