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Gleevec inhibits β-amyloid production but not Notch cleavage
Amyloid-β (Aβ) peptides, consisting mainly of 40 and 42 aa (Aβ40 and Aβ42, respectively), are metabolites of the amyloid precursor protein and are believed to be major pathological determinants of Alzheimer's disease. The proteolytic cleavages that form the Aβ N and C termini are catalyzed by β...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC218777/ https://ncbi.nlm.nih.gov/pubmed/14523244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1534745100 |
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